Livedoid vasculitis
Livedoid vasculitis Morbus cutaneus chronicus est praecipue in iuvenibus ad aetatem medium feminas. Unum acrononymum ad describenda lineamenta adhibitum est “ulcera purpurica dolorosa cum pattern reticulato extremitatum inferiorum” (PURPLE). Associatur cum pluribus conditionibus, inclusis hypertensione venosa chronica et varicositatibus.
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In anno 2022 Stiftung Warentest ex Germania provenit, satisfactio consumptoria cum ModelDerm paulo minus fuit quam cum consultationibus telemedicinis solutis.
In anno 2022 Stiftung Warentest ex Germania provenit, satisfactio consumptoria cum ModelDerm paulo minus fuit quam cum consultationibus telemedicinis solutis.
Dolore (pain) comitari potest.
relevance score : -100.0%
ReferencesLivedoid vasculopathy est rara conditio cutis quae ulceribus recidivis in cruribus inferioribus causat, relinquens cicatrices pallidas, quae atrophie blanche appellantur.
Livedoid vasculopathy (LV) is a rare thrombotic vasculopathy of the dermis characterized by painful, relapsing ulcers over the lower extremities. Diagnosis is challenging due to the overlap in clinical appearance and nomenclature with other skin disorders. Treatment selection is complicated by poor understanding of the pathogenesis of LV and lack of robust clinical trials evaluating therapy efficacy. The terminology and pathophysiology of LV are reviewed here, along with its epidemiology, clinical and histologic features, and treatment options. A diagnostic pathway is suggested to guide providers in evaluating for comorbidities, referring to appropriate specialists, and choosing from the available classes of therapy.
Livedoid vasculopathy (LV) is a rare thrombotic vasculopathy of the dermis characterized by painful, relapsing ulcers over the lower extremities. Diagnosis is challenging due to the overlap in clinical appearance and nomenclature with other skin disorders. Treatment selection is complicated by poor understanding of the pathogenesis of LV and lack of robust clinical trials evaluating therapy efficacy. The terminology and pathophysiology of LV are reviewed here, along with its epidemiology, clinical and histologic features, and treatment options. A diagnostic pathway is suggested to guide providers in evaluating for comorbidities, referring to appropriate specialists, and choosing from the available classes of therapy.
Vasculopatia livedoides (Livedoid vasculopathy) rara conditio cutis est quae in cruribus ulcera frequentissima facit, cum cicatricibus pallidis relatis, quae atrophiae albae notae sunt. Dum accurata causa adhuc obscura est, creditur hypercoagulabilitas (hypercoagulability) esse principalis factor, cum inflammatio partes secundarias agit. Factores ad coagulationem conferentes includunt: defectus proteinorum C et S, mutationes geneticae sicut factor V Leiden, defectus antithrombinum III, mutationes genei prothrombin, altae concentrationes homocysteinae. In biopsiis, conditio sanguinem concretum intra vasa ostendit, crassitudinem parietum vasorum et cicatricem. Curatio involvit accessum multipremium ad impediendam coagulationem sanguinis cum medicaminibus anti‑platelet (anti‑platelet drugs), anticoagulantia (blood thinners) et therapia fibrinolytica. Varia medicamenta ad hanc cutis conditionem adhiberi possunt – colchicina (colchicine), hydroxychloroquinum (hydroxychloroquine), vasodilatatores (vasodilators), immunosuppressores (immunosuppressants).
Livedoid vasculopathy is a rare skin condition that causes recurring ulcers on the lower legs, leaving behind pale scars known as atrophie blanche. While the exact cause is still unclear, it's believed that increased blood clotting (hypercoagulability) is the main factor, with inflammation playing a secondary role. Factors contributing to clotting include as follows - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. In biopsies, the condition shows blood clots inside vessels, thickening of vessel walls, and scarring. Treatment involves a multi-pronged approach focusing on preventing blood clots with medications like anti-platelet drugs, blood thinners, and fibrinolytic therapy. Various drugs can be used for this skin condition - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy is a rare skin condition that causes recurring ulcers on the lower legs, leaving behind pale scars known as atrophie blanche. While the exact cause is still unclear, it's believed that increased blood clotting (hypercoagulability) is the main factor, with inflammation playing a secondary role. Factors contributing to clotting include as follows - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. In biopsies, the condition shows blood clots inside vessels, thickening of vessel walls, and scarring. Treatment involves a multi-pronged approach focusing on preventing blood clots with medications like anti-platelet drugs, blood thinners, and fibrinolytic therapy. Various drugs can be used for this skin condition - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Vasculopathia livedoides (Livedoid vasculopathy) rara conditio est ubi laesiones in utris cruribus occurrunt. Activitas thrombotica auctus et activitas fibrinolytica diminuta, una cum damno endothelialium, creduntur causam formandi thrombum in vasculis capillaribus esse. Praesertim inter aetates XV et L feminas tres vicibus magis frequens est quam viros. Cessatio fumandi, cura vulnerum, et usus medicamentorum anticoagulantium et antiplateletorum efficax est.
Livedoid vasculopathy is a rare vasculopathy that is typically characterized by bilateral lower limb lesions. Increased thrombotic activity and decreased fibrinolytic activity along with endothelial damage are believed to be the cause of thrombus formation in the capillary vasculature. It is 3 times more common in females than in males, especially in patients between the ages of 15 to 50 years. There is no definite first-line treatment, but general measures like smoking cessation, wound care, and pharmacological measures like anticoagulants and antiplatelets have shown good results.
Livedoid vasculopathy is a rare vasculopathy that is typically characterized by bilateral lower limb lesions. Increased thrombotic activity and decreased fibrinolytic activity along with endothelial damage are believed to be the cause of thrombus formation in the capillary vasculature. It is 3 times more common in females than in males, especially in patients between the ages of 15 to 50 years. There is no definite first-line treatment, but general measures like smoking cessation, wound care, and pharmacological measures like anticoagulants and antiplatelets have shown good results.
